उत्तीसंवर्धनामध्ये कर्करोगाच्या पेशी ह्या त्यांची अनियंत्रीत वाढ व ________ आकारामुळे वेगळ्या आढळतात.
(1) लांबट
(2) गोल
(3) पंचकोनी
(4) षट्कोनी

The correct answer is Option B (Round).

Key Points:
• Core Concept
• In vitro cell biology examines cellular morphology and phenotypic alterations during oncogenic transformation.
• Why Correct
• Normal cultured adherent cells (like fibroblasts and epithelial cells) display contact inhibition, spreading out with flat, elongated, or polygonal shapes firmly anchored to culture plates.
• Transformed cancer cells lose contact inhibition and anchorage dependence, disassembling their internal cytoskeletal actin stress fibers. As a result, they detach, round up, and assume a characteristic rounded (गोल / spherical) morphology while piling up in irregular multi-layered foci.
• Key Details
• Cancer cells exhibit high nuclear-to-cytoplasmic ratios and altered surface glycoproteins along with this spherical/round shape.
• Exam Traps
• Normal cells are elongated/fibroblastic; malignant cells lose attachment tension and become conspicuously round.
• Other Options
• Elongated (Option 1) describes healthy fibroblastic morphology.
• Pentagonal/Hexagonal (Options 3 & 4) represent normal organized epithelial cobblestone sheets.
• Key Takeaway: In cell culture, transformed cancer cells lose cytoskeletal organization and become rounded in shape.